Acute promyelocytic leukemia: from genetics to treatment

Acute promyelocytic leukemia: from genetics to treatment.

A CUTE PROMYELOCYTIC leukemia (APL) has aroused interest well beyond the hematologic field during the last 4 to 5 years. Two features, both of which are unique to APL, have attracted the attention of various sectors of biomedical research: (1) the remission of the disease obtained with retinoic acid (RA) treatment, whose mechanism of action consists in inducing the APL blasts to differentiate t...

Treatment of acute promyelocytic leukemia.

Treatment of acute promyelocytic leukemia.

Cure of acute promyelocytic leukemia (APL) is now a possibility for most patients through the use of state-of-the-art treatments, which include simultaneous administration of all-trans retinoic acid (ATRA) and anthracycline-based chemotherapy for induction and consolidation, as well as ATRA-based maintenance. Risk-adapted strategies to modulate treatment intensity may be an effective approach t...

Current treatment of acute promyelocytic leukemia.

Acute Appendicitis Secondary to Acute Promyelocytic Leukemia

BACKGROUND The gastrointestinal tract is a rare site for extramedullary involvement in acute promyelocytic leukemia (APL). CASE REPORT A 43-year-old female with no past medical history presented complaining of mild abdominal pain, fever, and chills for the past day. On examination, she was tachycardic and febrile, with mild tenderness of her right lower quadrant and without signs of peritonea...